In Vitro and In Vivo Antifibrotic Effects of Fraxetin on Renal Interstitial Fibrosis via the ERK Signaling Pathway

In Vitro and In Vivo Antifibrotic Effects of Fraxetin on Renal Interstitial Fibrosis via the ERK Signaling Pathway

Fraxetin, a natural derivative of coumarin, is known to have anti-inflammatory, anti-oxidant, and hepatoprotective effects in multiple diseases and in liver fibrosis. Whether fraxetin exerts similar effects against renal fibrosis is unknown. In a Unilateral Ureteral Obstruction (UUO) mouse model of...

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Bibliographic Details
Main Authors: Yi-Hsien Hsieh, Tung-Wei Hung, Yong-Syuan Chen, Yi-Ning Huang, Hui-Ling Chiou, Chu-Che Lee, Jen-Pi Tsai
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Toxins
Subjects:
chronic kidney disease
fraxetin
indoxyl sulfate
α-SMA
ERK
Online Access:https://www.mdpi.com/2072-6651/13/7/474

Internet

https://www.mdpi.com/2072-6651/13/7/474

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