Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression

Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression

Background : Cardiac glycosides such as digitoxin have been shown to directly cause apoptotic death of cancer cells both in vitro, and in vivo. However, the mechanism connecting cardiac glycoside action to apoptosis is not known. It has been reported that compounds resembling digitoxin are able to r...

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Bibliographic Details
Main Authors: Qing Feng Yang, Clifton L Dalgard, Ofer Eidelman, Catherine Jozwik, Bette S Pollard, Meera Srivastava, Harvey B Pollard
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Carcinogenesis
Subjects:
Cardiac glycosides
c-MYC
nuclear factor of activated T-cells
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=8;epage=8;aulast=Yang

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