Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons.

Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons.

Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer's disease (AD) and related tauopathies. Several attempts have been made to promote clearance of pathological tau (p-Tau) from neurons. Transcription factor EB (TFEB) has...

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Bibliographic Details
Main Authors: Jessica L Binder, Praveen Chander, Vojo Deretic, Jason P Weick, Kiran Bhaskar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0230026

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