Current Topics in Pharmacological Research on Bone Metabolism: Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts

Abstract.: Despite the extensive use of bisphosphonates (BPs) in the treatment of metabolic bone diseases associated with increased osteoclastic bone resorption, the precise mechanism of their action on bone metabolism is still unclear. To clarify at which stages of osteoclast differentiation and ac...

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Bibliographic Details
Main Authors: Keiko Suzuki, Sadaaki Takeyama, Yasushi Sakai, Shoji Yamada, Hisashi Shinoda
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131934513X