The Role of microRNAs in Heart Failure: A Systematic Review
MicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We...
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doaj-7cd15f498c4c4583b5e4a1d8780e695b2020-11-25T03:59:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-10-01710.3389/fcvm.2020.00161534693The Role of microRNAs in Heart Failure: A Systematic ReviewAna Peterlin0Karolina Počivavšek1Danijel Petrovič2Borut Peterlin3Faculty of Medicine, Institute of Histology and Embryology, University of Ljubljana, Ljubljana, SloveniaDepartment of Cardiovascular Surgery, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Institute of Histology and Embryology, University of Ljubljana, Ljubljana, SloveniaClinical Institute of Genomic Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaMicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We identified 72 differentially expressed microRNA molecules among groups of heart failure patients and control groups by searching the PubMed database. We did not identify a substantial overlap of differentially expressed microRNAs among different studies; only five microRNAs (miR-1228, miR-122, miR-423-5p, miR-142-3p, and exosomal miR-92b-5p) were differentially expressed in more than one included study. Gene set enrichment analysis, based on the gene targets of microRNAs presented in the included studies, showed that gene targets of differentially expressed microRNAs were enriched in the MAPK, TGFβ, PI3K-Akt, and IL-2 signaling pathways, as well as apoptosis pathway, p53 activity regulation, and angiogenesis pathway. Results of our systematic review show that there is currently insufficient support for the use of any of the presented microRNAs as pathophysiological or prognostic biomarkers in the clinical setting.https://www.frontiersin.org/article/10.3389/fcvm.2020.00161/fullheart failurebiomarker (BM)epigenetics (DNA methylationhistone modifications)microRNA (miR)systematic (literature) review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Peterlin Karolina Počivavšek Danijel Petrovič Borut Peterlin |
spellingShingle |
Ana Peterlin Karolina Počivavšek Danijel Petrovič Borut Peterlin The Role of microRNAs in Heart Failure: A Systematic Review Frontiers in Cardiovascular Medicine heart failure biomarker (BM) epigenetics (DNA methylation histone modifications) microRNA (miR) systematic (literature) review |
author_facet |
Ana Peterlin Karolina Počivavšek Danijel Petrovič Borut Peterlin |
author_sort |
Ana Peterlin |
title |
The Role of microRNAs in Heart Failure: A Systematic Review |
title_short |
The Role of microRNAs in Heart Failure: A Systematic Review |
title_full |
The Role of microRNAs in Heart Failure: A Systematic Review |
title_fullStr |
The Role of microRNAs in Heart Failure: A Systematic Review |
title_full_unstemmed |
The Role of microRNAs in Heart Failure: A Systematic Review |
title_sort |
role of micrornas in heart failure: a systematic review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2020-10-01 |
description |
MicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We identified 72 differentially expressed microRNA molecules among groups of heart failure patients and control groups by searching the PubMed database. We did not identify a substantial overlap of differentially expressed microRNAs among different studies; only five microRNAs (miR-1228, miR-122, miR-423-5p, miR-142-3p, and exosomal miR-92b-5p) were differentially expressed in more than one included study. Gene set enrichment analysis, based on the gene targets of microRNAs presented in the included studies, showed that gene targets of differentially expressed microRNAs were enriched in the MAPK, TGFβ, PI3K-Akt, and IL-2 signaling pathways, as well as apoptosis pathway, p53 activity regulation, and angiogenesis pathway. Results of our systematic review show that there is currently insufficient support for the use of any of the presented microRNAs as pathophysiological or prognostic biomarkers in the clinical setting. |
topic |
heart failure biomarker (BM) epigenetics (DNA methylation histone modifications) microRNA (miR) systematic (literature) review |
url |
https://www.frontiersin.org/article/10.3389/fcvm.2020.00161/full |
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