The Role of microRNAs in Heart Failure: A Systematic Review

MicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We...

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Main Authors: Ana Peterlin, Karolina Počivavšek, Danijel Petrovič, Borut Peterlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00161/full
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spelling doaj-7cd15f498c4c4583b5e4a1d8780e695b2020-11-25T03:59:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2020-10-01710.3389/fcvm.2020.00161534693The Role of microRNAs in Heart Failure: A Systematic ReviewAna Peterlin0Karolina Počivavšek1Danijel Petrovič2Borut Peterlin3Faculty of Medicine, Institute of Histology and Embryology, University of Ljubljana, Ljubljana, SloveniaDepartment of Cardiovascular Surgery, University Medical Centre Ljubljana, Ljubljana, SloveniaFaculty of Medicine, Institute of Histology and Embryology, University of Ljubljana, Ljubljana, SloveniaClinical Institute of Genomic Medicine, University Medical Centre Ljubljana, Ljubljana, SloveniaMicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We identified 72 differentially expressed microRNA molecules among groups of heart failure patients and control groups by searching the PubMed database. We did not identify a substantial overlap of differentially expressed microRNAs among different studies; only five microRNAs (miR-1228, miR-122, miR-423-5p, miR-142-3p, and exosomal miR-92b-5p) were differentially expressed in more than one included study. Gene set enrichment analysis, based on the gene targets of microRNAs presented in the included studies, showed that gene targets of differentially expressed microRNAs were enriched in the MAPK, TGFβ, PI3K-Akt, and IL-2 signaling pathways, as well as apoptosis pathway, p53 activity regulation, and angiogenesis pathway. Results of our systematic review show that there is currently insufficient support for the use of any of the presented microRNAs as pathophysiological or prognostic biomarkers in the clinical setting.https://www.frontiersin.org/article/10.3389/fcvm.2020.00161/fullheart failurebiomarker (BM)epigenetics (DNA methylationhistone modifications)microRNA (miR)systematic (literature) review
collection DOAJ
language English
format Article
sources DOAJ
author Ana Peterlin
Karolina Počivavšek
Danijel Petrovič
Borut Peterlin
spellingShingle Ana Peterlin
Karolina Počivavšek
Danijel Petrovič
Borut Peterlin
The Role of microRNAs in Heart Failure: A Systematic Review
Frontiers in Cardiovascular Medicine
heart failure
biomarker (BM)
epigenetics (DNA methylation
histone modifications)
microRNA (miR)
systematic (literature) review
author_facet Ana Peterlin
Karolina Počivavšek
Danijel Petrovič
Borut Peterlin
author_sort Ana Peterlin
title The Role of microRNAs in Heart Failure: A Systematic Review
title_short The Role of microRNAs in Heart Failure: A Systematic Review
title_full The Role of microRNAs in Heart Failure: A Systematic Review
title_fullStr The Role of microRNAs in Heart Failure: A Systematic Review
title_full_unstemmed The Role of microRNAs in Heart Failure: A Systematic Review
title_sort role of micrornas in heart failure: a systematic review
publisher Frontiers Media S.A.
series Frontiers in Cardiovascular Medicine
issn 2297-055X
publishDate 2020-10-01
description MicroRNAs are highly investigated for their role in the pathogenesis of cardiovascular diseases. Nevertheless, evidence for clinical implementation is still lacking. In our systematic review, we evaluated the potential of microRNAs as pathophysiological and diagnostic biomarkers of heart failure. We identified 72 differentially expressed microRNA molecules among groups of heart failure patients and control groups by searching the PubMed database. We did not identify a substantial overlap of differentially expressed microRNAs among different studies; only five microRNAs (miR-1228, miR-122, miR-423-5p, miR-142-3p, and exosomal miR-92b-5p) were differentially expressed in more than one included study. Gene set enrichment analysis, based on the gene targets of microRNAs presented in the included studies, showed that gene targets of differentially expressed microRNAs were enriched in the MAPK, TGFβ, PI3K-Akt, and IL-2 signaling pathways, as well as apoptosis pathway, p53 activity regulation, and angiogenesis pathway. Results of our systematic review show that there is currently insufficient support for the use of any of the presented microRNAs as pathophysiological or prognostic biomarkers in the clinical setting.
topic heart failure
biomarker (BM)
epigenetics (DNA methylation
histone modifications)
microRNA (miR)
systematic (literature) review
url https://www.frontiersin.org/article/10.3389/fcvm.2020.00161/full
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