mTORC2 affects the maintenance of the muscle stem cell pool

mTORC2 affects the maintenance of the muscle stem cell pool

Abstract Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, PKC, and SGK. Inactivation of mTORC2 signaling in adult skeletal muscle...

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Bibliographic Details
Main Authors: Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard, Markus A. Rüegg
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Skeletal Muscle
Subjects:
mTORC2
Rictor
Muscle regeneration
Muscle stem cells
Online Access:https://doi.org/10.1186/s13395-019-0217-y

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