Response of Cisplatin Resistant Skov-3 Cells to [Pt(O,O′-Acac)(γ-Acac)(DMS)] Treatment Revealed by a Metabolomic 1H-NMR Study

Response of Cisplatin Resistant Skov-3 Cells to [Pt(O,O′-Acac)(γ-Acac)(DMS)] Treatment Revealed by a Metabolomic 1H-NMR Study

The novel [Pt(O,O′-acac)(γ-acac)(DMS)], Ptac2S, Pt(II) complex has recently gained increasing attention as a potential anticancer agent for its pharmacological activity shown in different tumor cell lines, studied both in vitro and in vivo. The mechanism of action of Ptac2S, oper...

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Bibliographic Details
Main Authors: Federica De Castro, Michele Benedetti, Giovanna Antonaci, Laura Del Coco, Sandra Angelica De Pascali, Antonella Muscella, Santo Marsigliante, Francesco Paolo Fanizzi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
cisplatin
platinum based drugs
[Pt(O,O′-acac)(γ-acac)(DMS)]
Ptac2S
Epithelial Ovarian Carcinoma
SKOV-3 cells
1H-NMR metabolomics
Online Access:http://www.mdpi.com/1420-3049/23/9/2301

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