NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs

NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs

During cardiopulmonary bypass (CPB), neutrophils become activated due to contact with extracorporeal surfaces and binding of complement fragments C3a and C5a, leading to extravasation and subsequent tissue damage. In this study, the effects of the leumedin NPC 15669 (N [9H - (2,7 dimethylfluorenyl -...

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Bibliographic Details
Main Authors: J. M. Bator, A. M. Gillinov, K. J. Zehr, J. M. Redmond, I. C. Wilson, A. Herskowitz, J. R. Connor, R. M. Burch, D. E. Cameron
Format: Article
Language:English
Published: Hindawi Limited 1993-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/S0962935193000201

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