Synthesis and cytotoxic activity of per-acetylated and halogenated derivatives of nucleosides in breast cancer cells

Synthesis and cytotoxic activity of per-acetylated and halogenated derivatives of nucleosides in breast cancer cells

ABSTRACT Objectives: To make the synthesis of halogenated derivatives on the nitrogenous base and their respective acyl ester and amide type derivatives for all hydroxyl and amine groups of the uridine and cytarabine nucleosides, and evaluate cytotoxicity against breast cancer cell line. Methods:...

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Bibliographic Details
Main Authors: JF Berrío Escobar, MH Pastrana Restrepo, E Galeano Jaramillo, DM Márquez Fernández, ME Márquez Fernández, A Martínez Martínez
Format: Article
Language:English
Published: Facultad de Farmacia, Universidad de Granada
Series:Ars Pharmaceutica
Subjects:
anticancer nucleoside
breast cancer
cytotoxic activity
esterification and halogenation reactions
uridine and cytarabine
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942017000400003&lng=en&tlng=en

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