Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells.

Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells.

The poly-ADP-ribosylation (PARsylation) activity of tankyrase (TNKS) regulates diverse physiological processes including energy metabolism and wnt/β-catenin signaling. This TNKS activity uses NAD+ as a co-substrate to post-translationally modify various acceptor proteins including TNKS itself. PARsy...

Full description

Bibliographic Details
Main Authors:	Linlin Zhong, Tsung-Yin J Yeh, Jun Hao, Nasim Pourtabatabaei, Sushil K Mahata, Jianhua Shao, Steven D Chessler, Nai-Wen Chi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4395342?pdf=render

Similar Items

Human Cytomegalovirus Inhibits the PARsylation Activity of Tankyrase—A Potential Strategy for Suppression of the Wnt Pathway
by: Sujayita Roy, et al.
Published: (2015-12-01)

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.
by: Estefania Martino-Echarri, et al.
Published: (2016-01-01)

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
by: Y Jeffrey Chiang, et al.
Published: (2008-07-01)

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation
by: Amit Bhardwaj, et al.
Published: (2017-12-01)

Arterial stimulation with simultaneous venous sampling for localizing insulinomas
by: Zhiyuan Wu, et al.
Published: (2018-02-01)

Insulinomas
by: Alfredo Jácome Roca
Published: (1986-04-01)

Insulinoma.
by: Halder P, et al.
Published: (1992-10-01)

Tankyrase inhibition sensitizes cells to CDK4 blockade.
by: Miguel Foronda, et al.
Published: (2019-01-01)

Intracellular distribution of Tankyrases as detected by multicolor immunofluorescence techniques
by: M.G. Bottone, et al.
Published: (2012-01-01)

Inhibitors of the tankyrases, triple-function targets in the cancer cell
by: Paine, Helen Angharad
Published: (2014)

A Case Report of Insulinoma Located with Calcium Stimulation Test
by: Mazhar Müslüm Tuna, et al.
Published: (2014-12-01)

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
by: Line Mygland, et al.
Published: (2021-07-01)

Extrapancreatic insulinoma
by: Robin Garg, et al.
Published: (2020-01-01)

INSULINOMA MALIGNO
by: Pedro Roberto Herrera-Favian, et al.
Published: (2017-09-01)

Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor
by: Hwani Ryu, et al.
Published: (2021-07-01)

Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.
by: Pan Ye, et al.
Published: (2018-09-01)

Novel binding mode of a potent and selective tankyrase inhibitor.
by: Hakan Gunaydin, et al.
Published: (2012-01-01)

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins
by: Wenqi Wang, et al.
Published: (2015-10-01)

Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity.
by: Nina Marie Pedersen, et al.
Published: (2016-01-01)

Experimental Research of Tankyrase1 Antisense Oligodeoxynucleotides on the Proliferation of Lung Cancer Cell Nodules
by: Chong Li, et al.
Published: (2010-06-01)

Identificação dos insulinomas pela ecoendoscopia Identification of insulinomas by endoscopic ultrasonography
by: José Celso Ardengh, et al.
Published: (2004-04-01)

Manejo diagnóstico del insulinoma pancreático Diagnostic evaluation of pancreatic insulinoma
by: M. J. Varas Lorenzo
Published: (2008-03-01)

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade.
by: Jiaoyuan Jia, et al.
Published: (2017-01-01)

Régulation du suppresseur d'invasion Arpin par les Tankyrases
by: Chemeris, Angelina
Published: (2018)

Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells
by: Dong Hoon Kang, et al.
Published: (2017-06-01)

Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
by: Zita Nagy, et al.
Published: (2016-02-01)

Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities
by: Esteban Zamudio-Martinez, et al.
Published: (2021-04-01)

Insulinoma and anaesthetic implications
by: Jyotsna Goswami, et al.
Published: (2012-01-01)

A WOMAN WITH INSULINOMA
by: M SAEIDI
Published: (2001-09-01)

Acanthosis nigricans in insulinoma
by: Viveka P Jyotsna, et al.
Published: (2014-01-01)

Anesthetic management of insulinoma
by: Leena Harshad Parate, et al.
Published: (2015-01-01)

Insulinoma pancreático gigante
by: Fernando Revoredo Rego, et al.
Published: (2016-03-01)

Insulinoma-Induced Hypoglycemia in a Patient with Insulinoma after Gastrojejunostomy for Prepyloric Ulcer
by: Yavuz Savas Koca, et al.
Published: (2015-01-01)

Tratamento cirúrgico dos insulinomas do pâncreas Surgical treatment of pancreatic insulinomas
by: Flávia Thaiana Bonato, et al.
Published: (2012-06-01)

Essentials of Insulinoma Localization with Selective Arterial Calcium Stimulation and Hepatic Venous Sampling
by: Ken Zhao, et al.
Published: (2020-09-01)

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
by: Nan Li, et al.
Published: (2019-09-01)

Manejo diagnóstico y terapéutico del insulinoma pancreático Diagnosis and treatment of pancreatic insulinoma
by: P. Priego, et al.
Published: (2007-04-01)

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.
by: Luned M Badder, et al.
Published: (2020-01-01)

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
by: Richard G James, et al.
Published: (2012-01-01)

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
by: Marinella G Callow, et al.
Published: (2011-01-01)

Cannot write session to /tmp/vufind_sessions/sess_shq19mnuumqocmpk4t10d53nhl