Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells

Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells

Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacterium for the ability to induce cell death in a range...

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Bibliographic Details
Main Authors: Lars Herfindal, Frode Selheim, Stein Ove Døskeland, Øystein Bruserud, Anders Brunsvik, Kolbjørn Zahlsen, Kristin F. Degnes, Knut Teigen, Håvard Sletta, Gro Gausdal, Lene E. Myhren, Gyrid Nygaard
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Marine Drugs
Subjects:
acute myeloid leukemia
natural products
daunorubicin
patient samples
Online Access:http://www.mdpi.com/1660-3397/11/2/332

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