Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein

It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conforma...

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Main Authors: Gert Weber, Gregory T. DeKoster, Nicole Holton, Kathleen B. Hall, Markus C. Wahl
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04561-6
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spelling doaj-7c88ead7df1b4767aff31b12d5ce58642021-05-11T09:22:17ZengNature Publishing GroupNature Communications2041-17232018-06-019111610.1038/s41467-018-04561-6Molecular principles underlying dual RNA specificity in the Drosophila SNF proteinGert Weber0Gregory T. DeKoster1Nicole Holton2Kathleen B. Hall3Markus C. Wahl4Laboratory of Structural Biochemistry, Freie Universität BerlinDepartment of Biochemistry and Molecular Biophysics, Washington University Medical SchoolLaboratory of Structural Biochemistry, Freie Universität BerlinDepartment of Biochemistry and Molecular Biophysics, Washington University Medical SchoolLaboratory of Structural Biochemistry, Freie Universität BerlinIt remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.https://doi.org/10.1038/s41467-018-04561-6
collection DOAJ
language English
format Article
sources DOAJ
author Gert Weber
Gregory T. DeKoster
Nicole Holton
Kathleen B. Hall
Markus C. Wahl
spellingShingle Gert Weber
Gregory T. DeKoster
Nicole Holton
Kathleen B. Hall
Markus C. Wahl
Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
Nature Communications
author_facet Gert Weber
Gregory T. DeKoster
Nicole Holton
Kathleen B. Hall
Markus C. Wahl
author_sort Gert Weber
title Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_short Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_full Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_fullStr Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_full_unstemmed Molecular principles underlying dual RNA specificity in the Drosophila SNF protein
title_sort molecular principles underlying dual rna specificity in the drosophila snf protein
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-06-01
description It remains poorly understood how a single RNA-binding protein recognizes diverse RNA targets. Here the authors use an integrative approach to study the binding of spliceosomal SNF protein to U1 and U2 small nuclear RNAs in the presence or absence of auxiliary protein U2A’ and show how SNF’s conformational dynamics are tuned to recognize different stem-loop structures.
url https://doi.org/10.1038/s41467-018-04561-6
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AT gregorytdekoster molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
AT nicoleholton molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
AT kathleenbhall molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
AT markuscwahl molecularprinciplesunderlyingdualrnaspecificityinthedrosophilasnfprotein
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