Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads

Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads

Calcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns...

Full description

Bibliographic Details
Main Authors: Yoshifumi Murata, Youko Kodama, Takashi Isobe, Kyoko Kofuji, Susumu Kawashima
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:International Journal of Polymer Science
Online Access:http://dx.doi.org/10.1155/2009/729057
id doaj-7c879eec95fe4e989efe27eb755f3b14
record_format Article
spelling doaj-7c879eec95fe4e989efe27eb755f3b142020-11-25T00:06:22ZengHindawi LimitedInternational Journal of Polymer Science1687-94221687-94302009-01-01200910.1155/2009/729057729057Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel BeadsYoshifumi Murata0Youko Kodama1Takashi Isobe2Kyoko Kofuji3Susumu Kawashima4Faculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanFaculty of Pharmaceutical Science, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa, Ishikawa 920-1181, JapanCalcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns showed that the calcium phosphate does not exist in crystalline form in the matrix. The initial release amount and release rate of a water-soluble drug, diclofenac, from the alginate gel beads could be controlled by modifying the composition of the matrix with calcium phosphate. In contrast, the release profile was not affected by the modification for hydrocortisone, a drug only slightly soluble in water.http://dx.doi.org/10.1155/2009/729057
collection DOAJ
language English
format Article
sources DOAJ
author Yoshifumi Murata
Youko Kodama
Takashi Isobe
Kyoko Kofuji
Susumu Kawashima
spellingShingle Yoshifumi Murata
Youko Kodama
Takashi Isobe
Kyoko Kofuji
Susumu Kawashima
Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
International Journal of Polymer Science
author_facet Yoshifumi Murata
Youko Kodama
Takashi Isobe
Kyoko Kofuji
Susumu Kawashima
author_sort Yoshifumi Murata
title Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
title_short Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
title_full Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
title_fullStr Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
title_full_unstemmed Drug Release Profile from Calcium-Induced Alginate-Phosphate Composite Gel Beads
title_sort drug release profile from calcium-induced alginate-phosphate composite gel beads
publisher Hindawi Limited
series International Journal of Polymer Science
issn 1687-9422
1687-9430
publishDate 2009-01-01
description Calcium-induced alginate-phosphate composite gel beads were prepared, and model drug release profiles were investigated in vitro. The formation of calcium phosphate in the alginate gel matrix was observed and did not affect the rheological properties of the hydrogel beads. X-ray diffraction patterns showed that the calcium phosphate does not exist in crystalline form in the matrix. The initial release amount and release rate of a water-soluble drug, diclofenac, from the alginate gel beads could be controlled by modifying the composition of the matrix with calcium phosphate. In contrast, the release profile was not affected by the modification for hydrocortisone, a drug only slightly soluble in water.
url http://dx.doi.org/10.1155/2009/729057
work_keys_str_mv AT yoshifumimurata drugreleaseprofilefromcalciuminducedalginatephosphatecompositegelbeads
AT youkokodama drugreleaseprofilefromcalciuminducedalginatephosphatecompositegelbeads
AT takashiisobe drugreleaseprofilefromcalciuminducedalginatephosphatecompositegelbeads
AT kyokokofuji drugreleaseprofilefromcalciuminducedalginatephosphatecompositegelbeads
AT susumukawashima drugreleaseprofilefromcalciuminducedalginatephosphatecompositegelbeads
_version_ 1725422429046571008

Similar Items