An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance

• Main Authors: Majed Alrobaian, Sana Al Azwari, Amany Belal, Hany A. Eldeab
• Format: Article
• Language: English
• Published: MDPI AG 2019-05-01
• Series: Molecules
• Subjects: green chemistry; microwave synthesis; pyridine galactosides; anticancer activity; antimicrobial; molecular docking
• Online Access: https://www.mdpi.com/1420-3049/24/10/1969

Two series of novel 5-arylazo-3-cyano-2-(2&#8243;,3&#8243;,4&#8243;,6&#8243;-tetra-<i>O</i>-acetyl-&#946;-<span style="font-variant: small-caps;">d</span>-galacto pyranosyloxy) pyridines and 3-cyano-2-(2&#8243;,3&#8243;,4&#8243;,6&#8243;-tetra-<i>O</i>-acetyl-&#946;-<span style="font-variant: small-caps;">d</span>-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR).