| Summary: | The antioxidant effects of individual natural compounds have been extensively investigated. However, studies on their
interactions are still lacking. This study aimed to observe the interaction effect of ginger extract (GE) combined with ascorbic
acid on antioxidant activity by applying response surface methodology. The results from the quadratic model showed that
individually tested DPPH free radical scavenging capacities of GE and ascorbic acid manifested positive effects on the
antioxidant index (AI%). However, interaction of their combination demonstrated an antagonistic effect that negatively
influenced the AI%. An optimization process revealed that the highest AI% could be achieved by applying maximum effective
concentrations of GE (0.49 mg/mL) and ascorbic acid (0.82 mg/mL). Although, the mechanisms behind these interactions need to
be further explored, the results of this study suggested that antagonistic interaction between the combination of ginger or other
herbal extracts with ascorbic acid should be taken into consideration to prevent any potential health complications.
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