Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives

Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives

In this study, 2-(N-pyrrolidine-alkyl) tanshinones bearing pyrrolidine groups were synthesized and the antibacterial mechanism was explored. These derivatives selectively elicited antibacterial activity against Gram-positive bacteria. Moreover, their antibacterial activities were time-, concentratio...

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Bibliographic Details
Main Authors: Dongdong Wang, Wuxia Zhang, Tingting Wang, Na Li, Haibo Mu, Jiwen Zhang, Jinyou Duan
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
tanshinone
pyrrolidine
antibacterial
reactive oxygen species (ROS)
membrane
Online Access:http://www.mdpi.com/1422-0067/16/8/17668

Internet

http://www.mdpi.com/1422-0067/16/8/17668

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