HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation.

Human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, impacts a multitude of cellular processes, including I-κB kinase (IKK)/NF-κB signaling, DNA damage repair, and mitosis. These activities of Tax have been implicated in the development of adult T-cell leukemia (ATL) in HTLV-...

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Bibliographic Details
Main Authors: Yik-Khuan Ho, Huijun Zhi, Tara Bowlin, Batsukh Dorjbal, Subha Philip, Muhammad Atif Zahoor, Hsiu-Ming Shih, Oliver John Semmes, Brian Schaefer, J N Mark Glover, Chou-Zen Giam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4540474?pdf=render

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http://europepmc.org/articles/PMC4540474?pdf=render

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