Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride

Propofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability of three propofol formulations, two with medium chain triglycerides and one with long ch...

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Main Authors: Nilsson Niklas, Nezvalova-Henriksen Katerina, Tho Ingunn
Format: Article
Language:English
Published: De Gruyter 2019-08-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
Online Access:https://doi.org/10.1515/pthp-2019-0014
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spelling doaj-7c5e73e68ef9434d8c047d235d4bca722021-10-02T19:03:45ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2019-08-0142778710.1515/pthp-2019-0014Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil HydrochlorideNilsson Niklas0Nezvalova-Henriksen Katerina1Tho Ingunn2Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, P.O.Box 1068 Blindern, Oslo0371, Norway; Oslo Hospital Pharmacy, Rikshospitalet, NorwayOslo Hospital Pharmacy, Rikshospitalet, Hospital Pharmacy Enterprise, Oslo0372, NorwayDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, P.O.Box 1068 Blindern, Oslo0371, NorwayPropofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability of three propofol formulations, two with medium chain triglycerides and one with long chain triglycerides, when administered together with remifentanil hydrochloride.https://doi.org/10.1515/pthp-2019-0014compatibilitysafe intravenous administrationanesthesiadroplet growthdestabilisationpfat5
collection DOAJ
language English
format Article
sources DOAJ
author Nilsson Niklas
Nezvalova-Henriksen Katerina
Tho Ingunn
spellingShingle Nilsson Niklas
Nezvalova-Henriksen Katerina
Tho Ingunn
Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride
Pharmaceutical Technology in Hospital Pharmacy
compatibility
safe intravenous administration
anesthesia
droplet growth
destabilisation
pfat5
author_facet Nilsson Niklas
Nezvalova-Henriksen Katerina
Tho Ingunn
author_sort Nilsson Niklas
title Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride
title_short Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride
title_full Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride
title_fullStr Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride
title_full_unstemmed Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride
title_sort emulsion stability of different intravenous propofol formulations in simulated co-administration with remifentanil hydrochloride
publisher De Gruyter
series Pharmaceutical Technology in Hospital Pharmacy
issn 2365-2411
2365-242X
publishDate 2019-08-01
description Propofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability of three propofol formulations, two with medium chain triglycerides and one with long chain triglycerides, when administered together with remifentanil hydrochloride.
topic compatibility
safe intravenous administration
anesthesia
droplet growth
destabilisation
pfat5
url https://doi.org/10.1515/pthp-2019-0014
work_keys_str_mv AT nilssonniklas emulsionstabilityofdifferentintravenouspropofolformulationsinsimulatedcoadministrationwithremifentanilhydrochloride
AT nezvalovahenriksenkaterina emulsionstabilityofdifferentintravenouspropofolformulationsinsimulatedcoadministrationwithremifentanilhydrochloride
AT thoingunn emulsionstabilityofdifferentintravenouspropofolformulationsinsimulatedcoadministrationwithremifentanilhydrochloride
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