Apo B100 similarities to viral proteins suggest basis for LDL-DNA binding and transfection capacity

Apo B100 similarities to viral proteins suggest basis for LDL-DNA binding and transfection capacity

LDL mediates transfection with plasmid DNA in a variety of cell types in vitro and in several tissues in vivo in the rat. The transfection capacity of LDL is based on apo B100, as arginine/lysine clusters, suggestive of nucleic acid-binding domains and nuclear localization signal sequences, are pres...

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Bibliographic Details
Main Authors: Juan Guevara, Jr., Nagindra Prashad, Boris Ermolinsky, John W. Gaubatz, Dongcheul Kang, Andrea E. Schwarzbach, David S. Loose, Natalia Valentinova Guevara
Format: Article
Language:English
Published: Elsevier 2010-07-01
Series:Journal of Lipid Research
Subjects:
Flaviviridae capsid/core proteins
synthetic peptides
KXXK motif
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370930

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http://www.sciencedirect.com/science/article/pii/S0022227520370930

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