Dielectrophoresis: A Review of Applications for Stem Cell Research

Dielectrophoresis: A Review of Applications for Stem Cell Research

Dielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels. Demonstrated capabilities include the enrichment of haematop...

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Main Authors: Ronald Pethig, Anoop Menachery, Steve Pells, Paul De Sousa
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2010/182581
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spelling doaj-7c5c607143494bbd9cac53bc8e2b71072020-11-25T00:49:55ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/182581182581Dielectrophoresis: A Review of Applications for Stem Cell ResearchRonald Pethig0Anoop Menachery1Steve Pells2Paul De Sousa3Institute for Integrated Micro and Nano Systems, Joint Research Institute for Integrated Systems, School of Engineering, The University of Edinburgh, Edinburgh EH9 3JF, UKInstitute for Integrated Micro and Nano Systems, Joint Research Institute for Integrated Systems, School of Engineering, The University of Edinburgh, Edinburgh EH9 3JF, UKMRC Centre for Regenerative Medicine, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UKMRC Centre for Regenerative Medicine, College of Medicine and Veterinary Medicine, The University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UKDielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels. Demonstrated capabilities include the enrichment of haematopoetic stem cells from bone marrow and peripheral blood, and adult stem cells from adipose tissue. Recent research suggests that this technique can predict the ultimate fate of neural stem cells after differentiation before the appearance of specific cell-surface proteins. This review summarises the properties of cells that contribute to their dielectrophoretic behaviour, and their relevance to stem cell research and translational applications.http://dx.doi.org/10.1155/2010/182581
collection DOAJ
language English
format Article
sources DOAJ
author Ronald Pethig
Anoop Menachery
Steve Pells
Paul De Sousa
spellingShingle Ronald Pethig
Anoop Menachery
Steve Pells
Paul De Sousa
Dielectrophoresis: A Review of Applications for Stem Cell Research
Journal of Biomedicine and Biotechnology
author_facet Ronald Pethig
Anoop Menachery
Steve Pells
Paul De Sousa
author_sort Ronald Pethig
title Dielectrophoresis: A Review of Applications for Stem Cell Research
title_short Dielectrophoresis: A Review of Applications for Stem Cell Research
title_full Dielectrophoresis: A Review of Applications for Stem Cell Research
title_fullStr Dielectrophoresis: A Review of Applications for Stem Cell Research
title_full_unstemmed Dielectrophoresis: A Review of Applications for Stem Cell Research
title_sort dielectrophoresis: a review of applications for stem cell research
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2010-01-01
description Dielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels. Demonstrated capabilities include the enrichment of haematopoetic stem cells from bone marrow and peripheral blood, and adult stem cells from adipose tissue. Recent research suggests that this technique can predict the ultimate fate of neural stem cells after differentiation before the appearance of specific cell-surface proteins. This review summarises the properties of cells that contribute to their dielectrophoretic behaviour, and their relevance to stem cell research and translational applications.
url http://dx.doi.org/10.1155/2010/182581
work_keys_str_mv AT ronaldpethig dielectrophoresisareviewofapplicationsforstemcellresearch
AT anoopmenachery dielectrophoresisareviewofapplicationsforstemcellresearch
AT stevepells dielectrophoresisareviewofapplicationsforstemcellresearch
AT pauldesousa dielectrophoresisareviewofapplicationsforstemcellresearch
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