Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection

Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection

The mechanisms by which HIV increases susceptibility to tuberculosis and other respiratory infections are incompletely understood. We used transcriptomics of paired whole bronchoalveolar lavage cells (BLCs) and peripheral blood mononuclear cells to compare the effect of HIV at the lung mucosal surfa...

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Bibliographic Details
Main Authors: Daniel M. Muema, Maphe Mthembu, Abigail E. Schiff, Urisha Singh, Björn Corleis, Dongquan Chen, Thierry Bassett, Sipho S. Rasehlo, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Zoey Mhlane, Taryn Naidoo, Dirhona Ramjit, Farina Karim, Douglas S. Kwon, Thumbi Ndung'u, Emily B. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
HIV
type I interferon
Cytotoxic CD8 T cells
lymphocyte infiltration
bronchoalveolar
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00864/full

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