High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells

High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells

Bupivacaine, a typical local anesthetic, induces neurotoxicity via reactive oxygen species regulation of apoptosis. High glucose could enhance bupivacaine-induced neurotoxicity through regulating oxidative stress, but the mechanism of it is not clear. Mitochondrial calcium uniporter (MCU), a key cha...

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Bibliographic Details
Main Authors:	Zhong-Jie Liu, Wei Zhao, Hong-Yi Lei, Hua-Li Xu, Lu-Ying Lai, Rui Xu, Shi-Yuan Xu
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2019/7192798

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