Harnessing the Microbiome to Enhance Cancer Immunotherapy

Harnessing the Microbiome to Enhance Cancer Immunotherapy

The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell...

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Main Authors: Michelle H. Nelson, Marshall A. Diven, Logan W. Huff, Chrystal M. Paulos
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2015/368736
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spelling doaj-7c49c95806da4fcf9ca0fe05d65903032020-11-24T22:38:33ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/368736368736Harnessing the Microbiome to Enhance Cancer ImmunotherapyMichelle H. Nelson0Marshall A. Diven1Logan W. Huff2Chrystal M. Paulos3Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USADepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USAThe microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to human malignancies.http://dx.doi.org/10.1155/2015/368736
collection DOAJ
language English
format Article
sources DOAJ
author Michelle H. Nelson
Marshall A. Diven
Logan W. Huff
Chrystal M. Paulos
spellingShingle Michelle H. Nelson
Marshall A. Diven
Logan W. Huff
Chrystal M. Paulos
Harnessing the Microbiome to Enhance Cancer Immunotherapy
Journal of Immunology Research
author_facet Michelle H. Nelson
Marshall A. Diven
Logan W. Huff
Chrystal M. Paulos
author_sort Michelle H. Nelson
title Harnessing the Microbiome to Enhance Cancer Immunotherapy
title_short Harnessing the Microbiome to Enhance Cancer Immunotherapy
title_full Harnessing the Microbiome to Enhance Cancer Immunotherapy
title_fullStr Harnessing the Microbiome to Enhance Cancer Immunotherapy
title_full_unstemmed Harnessing the Microbiome to Enhance Cancer Immunotherapy
title_sort harnessing the microbiome to enhance cancer immunotherapy
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-8861
2314-7156
publishDate 2015-01-01
description The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota to enhance T cell-based therapies in cancer patients. Finally, we highlight recent developments in tumor immunotherapy, particularly novel ways to modulate the microbiome and memory T cell responses to human malignancies.
url http://dx.doi.org/10.1155/2015/368736
work_keys_str_mv AT michellehnelson harnessingthemicrobiometoenhancecancerimmunotherapy
AT marshalladiven harnessingthemicrobiometoenhancecancerimmunotherapy
AT loganwhuff harnessingthemicrobiometoenhancecancerimmunotherapy
AT chrystalmpaulos harnessingthemicrobiometoenhancecancerimmunotherapy
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