Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis.

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis.

Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied platinum-based chemotherapeutics and drugs from a...

Full description

Bibliographic Details
Main Authors:	Hristo P Varbanov, Fabien Kuttler, Damiano Banfi, Gerardo Turcatti, Paul J Dyson
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0211268

Similar Items

Repositioning approved drugs for the treatment of problematic cancers using a screening approach.
by: Hristo P Varbanov, et al.
Published: (2017-01-01)

The Effects of WISP1 Polymorphisms on the Prognosis of Lung Cancer Patients with Platinum-Based Chemotherapy
by: He J, et al.
Published: (2021-09-01)

Elevated serum levels of vascular endothelial growth factor predict a poor prognosis of platinum-based chemotherapy in non-small cell lung cancer
by: Zang JL, et al.
Published: (2017-01-01)

The expression of ERCC1 and BRCA1 predicts prognosis of platinum-based chemotherapy in urothelial cancer
by: Song WH, et al.
Published: (2016-06-01)

High-throughput, nonperturbing quantification of lipid droplets with digital holographic microscopy
by: Vasco Campos, et al.
Published: (2018-01-01)

Nimotuzumab plus platinum-based chemotherapy platinum-based chemotherapy alone in patients with recurrent or metastatic nasopharyngeal carcinoma
by: Yunshu Zhu, et al.
Published: (2020-09-01)

Discovering novel platinum structures
by: Mabunda, Khanyisa Prudence
Published: (2015)

BMP-4 Genetic Variants and Protein Expression Are Associated with Platinum-Based Chemotherapy Response and Prognosis in NSCLC
by: Sun Xian, et al.
Published: (2014-01-01)

Correlation of DLL3 Expression with Platinum-based Chemotherapy Efficacy and Prognosis of Advanced Small Cell Lung Cancer
by: HAN Shuhua, et al.
Published: (2020-11-01)

The Association Between Heat-Shock Protein Polymorphisms and Prognosis in Lung Cancer Patients Treated With Platinum-Based Chemotherapy
by: Ting Zou, et al.
Published: (2020-07-01)

Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review
by: Afifah NN, et al.
Published: (2020-10-01)

THE ROLE OF PREOPERATIVE REGIONAL CHEMOTHERAPY FOR COLORECTAL METASTASES IN POOR PROGNOSIS PATIENTS
by: S. A. Lazarev, et al.
Published: (2015-02-01)

Non-Coding RNA Polymorphisms (rs2910164 and rs1333049) Associated With Prognosis of Lung Cancer Under Platinum-Based Chemotherapy
by: Yi-Xin Chen, et al.
Published: (2021-09-01)

Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy
by: Keck Bastian, et al.
Published: (2013-02-01)

Elevated Stratifin promotes cisplatin-based chemotherapy failure and poor prognosis in non-small cell lung cancer
by: Yu-Shui Ma, et al.
Published: (2021-09-01)

Potential predictors for chemotherapeutic response and prognosis in epithelial ovarian, fallopian tube and primary peritoneal cancer patients treated with platinum-based chemotherapy
by: Dhammapoj Jeerakornpassawat, et al.
Published: (2020-01-01)

MicroRNA-223 is Associated with Resistance Towards Platinum-based Chemotherapy and Worse Prognosis in Indonesian Triple-negative Breast Cancer Patients
by: Purwanto I, et al.
Published: (2021-01-01)

Risk factors for chemotherapy‐induced peripheral neuropathy in patients receiving taxane‐ and platinum‐based chemotherapy
by: Alex Molassiotis, et al.
Published: (2019-06-01)

Positive plasma cotinine during platinum-based chemotherapy is associated with poor response rate in advanced non-small cell lung cancer patients.
by: Philippine Dacosta-Noble, et al.
Published: (2019-01-01)

ERCC1 as a marker of prognosis and sensitivity to platinum-based chemotherapy in patients with stage III–IV non-small cell lung cancer
by: O. P. Kolesnik, et al.
Published: (2020-06-01)

Ovarian Carcinosarcoma: Effects of Cytoreductive Status and Platinum-Based Chemotherapy on Survival
by: Amelia M. Jernigan, et al.
Published: (2013-01-01)

Impact of platinum/pemetrexed combination versus other platinum-based regimens on adjuvant chemotherapy in resected lung adenocarcinoma
by: Xiaoyu Zhai, et al.
Published: (2017-05-01)

Low expression of NCALD is associated with chemotherapy resistance and poor prognosis in epithelial ovarian cancer
by: Li-yuan Feng, et al.
Published: (2020-03-01)

High VCAM-1 Predicts Poor Prognosis and is Associated with Chemotherapy Resistance in Nasopharyngeal Carcinoma
by: Huang Y, et al.
Published: (2021-03-01)

Platinum-based versus non-platinum-based chemotherapy as first line treatment of inoperable, advanced gastric adenocarcinoma: a meta-analysis.
by: Wei-Wei Chen, et al.
Published: (2013-01-01)

Development and Validation of Liquid Chromatography-Based Methods to Assess the Lipophilicity of Cytotoxic Platinum(IV) Complexes
by: Matthias H. M. Klose, et al.
Published: (2018-12-01)

Screening of biomarkers for prediction of response to and prognosis after chemotherapy for breast cancers
by: Bing F, et al.
Published: (2016-05-01)

Trends in the utilizaton of platinum-based neoadjuvant chemotherapy for upper tract urothelial carcinoma
by: H. Horiguchi, et al.
Published: (2020-07-01)

Effect of XPC polymorphisms on the response to platinum-based chemotherapy: a meta-analysis
by: Xie C, et al.
Published: (2019-05-01)

Vestibulotoxicity Associated With Platinum-Based Chemotherapy in Survivors of Cancer: A Scoping Review
by: Pattarawadee Prayuenyong, et al.
Published: (2018-09-01)

Gold as a Possible Alternative to Platinum-Based Chemotherapy for Colon Cancer Treatment
by: Inés Mármol, et al.
Published: (2019-06-01)

Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer
by: Vanita Noronha, et al.
Published: (2012-01-01)

Pharmacogenomics for the efficacy of platinum-based chemotherapy: Old drugs, new integrated perspective
by: Chen-Xue Mao, et al.
Published: (2020-06-01)

Combination chemotherapy in the treatment of breast cancer patients with metastatic brain involvement and a poor prognosis
by: D. R. Naskhletashvili, et al.
Published: (2014-07-01)

Lymphocyte-to-Monocyte Ratio is Associated with the Poor Prognosis of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
by: Ma Y, et al.
Published: (2021-02-01)

The prolonged interval between induction chemotherapy and radiotherapy is associated with poor prognosis in patients with nasopharyngeal carcinoma
by: Liang Peng, et al.
Published: (2019-01-01)

High ABCG4 Expression Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer Patients Treated with Cisplatin-Based Chemotherapy.
by: Guang Yang, et al.
Published: (2015-01-01)

Influence of Programmed Death Ligand-1-Gene Polymorphism rs822336 on the Prognosis and Safety of Postoperative Patients with NSCLC Who Received Platinum-Based Adjuvant Chemotherapy
by: Zhao M, et al.
Published: (2020-08-01)

Metronomic Outpatient-Based Chemotherapy with 5′-DFUR and Low-Dose Cisplatin for Conventional Platinum-Based Chemotherapy-Resistant Advanced Urothelial Cancer
by: Tomohiko Hara, et al.
Published: (2007-01-01)

Organ-Specific Therapeutic Effect of Paclitaxel and Carboplatin Chemotherapy After Platinum-Based Chemotherapy and Pembrolizumab for Metastatic Urothelial Carcinoma
by: Furubayashi N, et al.
Published: (2020-10-01)