Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET/CT

• Main Authors: Sophie E. Vollenbrock, MD, Marlies E. Nowee, MD, PhD, Francine E.M. Voncken, MD, Alexis N.T.J. Kotte, PhD, Lucas Goense, MD, PhD, Peter S.N. van Rossum, MD, PhD, Astrid L.H.M.W. van Lier, PhD, Stijn W. Heijmink, MD, PhD, Annemarieke Bartels-Rutten, MD, PhD, Frank J. Wessels, MD, Berthe M.P. Aleman, MD, PhD, Luc Dewit, MD, PhD, Linda G.W. Kerkmeijer, MD, PhD, Edwin P.M. Jansen, MD, PhD, Martijn Intven, MD, PhD, Irene M. Lips, MD, PhD, Gert J. Meijer, PhD, Jasper Nijkamp, PhD
• Format: Article
• Language: English
• Published: Elsevier 2019-10-01
• Series: Advances in Radiation Oncology
• Online Access: http://www.sciencedirect.com/science/article/pii/S2452109419300521

Purpose: Current delineation of the gross tumor volume (GTV) in esophageal cancer relies on computed tomography (CT) and combination with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). There is increasing interest in integrating magnetic resonance imaging (MRI) in radiation treatment, which can potentially obviate CT- or FDG-PET/CT–based delineation. The aim of this study is to evaluate the feasibility of target delineation on T2-weighted (T2W) MRI and T2W including diffusion-weighted MRI (T2W + DW-MRI) compared with current-practice FDG-PET/CT. Methods: Ten observers delineated primary esophageal tumor GTVs of 6 patients on FDG-PET/CT, T2W-MRI, and T2W + DW-MRI. GTVs, generalized conformity indices, in-slice delineation variation (root mean square), and standard deviations in the position of the most cranial and caudal delineated slice were calculated. Results: Delineations on MRI showed smaller GTVs compared with FDG-PET/CT–based delineations. The main variation was seen at the cranial and caudal border. No differences were observed in conformity indices (FDG-PET/CT, 0.68; T2W-MRI, 0.66; T2W + DW-MRI, 0.68) and in-slice variation (root mean square, 0.13 cm on FDG-PET/CT; 0.10 cm on T2W-MRI; 0.14 cm on T2W + DW-MRI). In the 2 tumors involving the gastroesophageal junction, addition of DW-MRI to T2W-MRI significantly decreased caudal border variation. Conclusions: MRI-based target delineation of the esophageal tumor is feasible with interobserver variability comparable to that with FDG-PET/CT, despite limited experience with delineation on MRI. Most variation was seen at cranial-caudal borders, and addition of DW-MRI to T2W-MRI may reduce caudal delineation variation of gastroesophageal junction tumors.