Randomized controlled trial about pain medication flupirtine ignores recent pharmacovigilance warnings

• Main Author: Puljak L
• Format: Article
• Language: English
• Published: Dove Medical Press 2018-01-01
• Series: Journal of Pain Research
• Subjects: flupirtine; pain; pharmacovigilance; liver; hepatotoxicity; trial registration
• Online Access: https://www.dovepress.com/randomized-controlled-trial-about-pain-medication-flupirtine-ignores-r-peer-reviewed-article-JPR
• ISSN: 1178-7090

Livia Puljak1,2 1Laboratory for Pain Research, University of Split School of Medicine, Split, Croatia; 2Department for Development, Research and Health Technology Assessment, Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, CroatiaOn October 16, 2017 in the Journal of Pain Research, a randomized controlled trial (RCT) comparing efficacy and safety of flupirtine versus piroxicam in postoperative pain in patients undergoing lower limb surgery was published.1 However, this paper fails to report important information. Author’s reply Sowmya Chinnaiyan,1 Narayana Sarala,1 Heddur Shanthappa Arun21Department of Pharmacology, 2Department of Orthopedics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India We thank Livia Puljak for the valuable insights on the article titled “A comparative study of efficacy and safety of flupirtine  versus piroxicam in postoperative pain in patients undergoing lower limb surgery” published in the Journal of Pain Research. The concerns highlighted in the Letter to the Editor have been answered.View the original paper by Chinnaiyan and colleagues.