Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives

Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives

Some novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline derivatives 8(a–f) were synthesized by reacting 5,7-dichloro-2-hydrazino-1,3-benzoxazole 4 and substituted-2-chloro-3-quinoline carbaldehydes using p-toluenesulfonic acid (PTSA) as a catalyst for the cyclisation. The target...

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Main Authors: N. D. Jayanna, H. M. Vagdevi, J. C. Dharshan, T. R. Prashith Kekuda
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/234074
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spelling doaj-7c2e9ec542a142499808da80f59ed0752020-11-24T22:26:35ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/234074234074Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline DerivativesN. D. Jayanna0H. M. Vagdevi1J. C. Dharshan2T. R. Prashith Kekuda3Department of Chemistry, Sahyadri Science College, Shimoga 577 203, IndiaDepartment of Chemistry, Sahyadri Science College, Shimoga 577 203, IndiaDepartment of PG Studies and Research in Industrial Chemistry, Sir M.V. Government Science College, Bommanakatte, Bhadravathi 577451, IndiaDepartment of Microbiology, Sahyadri Science College, Shimoga 577 203, IndiaSome novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline derivatives 8(a–f) were synthesized by reacting 5,7-dichloro-2-hydrazino-1,3-benzoxazole 4 and substituted-2-chloro-3-quinoline carbaldehydes using p-toluenesulfonic acid (PTSA) as a catalyst for the cyclisation. The target molecules have been characterized by IR, 1H NMR, 13C NMR, and mass spectral studies. The synthesized compounds were screened for biological activities, and some of the compounds have exhibited encouraging antibacterial and antioxidant activities. The compounds 8a and 8e showed potent antibacterial activity, whereas the compounds 8e and 8f act as antioxidants.http://dx.doi.org/10.1155/2013/234074
collection DOAJ
language English
format Article
sources DOAJ
author N. D. Jayanna
H. M. Vagdevi
J. C. Dharshan
T. R. Prashith Kekuda
spellingShingle N. D. Jayanna
H. M. Vagdevi
J. C. Dharshan
T. R. Prashith Kekuda
Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives
Journal of Chemistry
author_facet N. D. Jayanna
H. M. Vagdevi
J. C. Dharshan
T. R. Prashith Kekuda
author_sort N. D. Jayanna
title Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives
title_short Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives
title_full Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives
title_fullStr Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives
title_full_unstemmed Synthesis, Antibacterial and Antioxidant Evaluation of Novel 1-(5,7-Dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline Derivatives
title_sort synthesis, antibacterial and antioxidant evaluation of novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-1h-pyrazolo[3,4-b]quinoline derivatives
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2013-01-01
description Some novel 1-(5,7-dichloro-1,3-benzoxazol-2-yl)-1H-pyrazolo[3,4-b]quinoline derivatives 8(a–f) were synthesized by reacting 5,7-dichloro-2-hydrazino-1,3-benzoxazole 4 and substituted-2-chloro-3-quinoline carbaldehydes using p-toluenesulfonic acid (PTSA) as a catalyst for the cyclisation. The target molecules have been characterized by IR, 1H NMR, 13C NMR, and mass spectral studies. The synthesized compounds were screened for biological activities, and some of the compounds have exhibited encouraging antibacterial and antioxidant activities. The compounds 8a and 8e showed potent antibacterial activity, whereas the compounds 8e and 8f act as antioxidants.
url http://dx.doi.org/10.1155/2013/234074
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