Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability ....

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Bibliographic Details
Main Authors: Demis Menolfi, Wenxia Jiang, Brian J. Lee, Tatiana Moiseeva, Zhengping Shao, Verna Estes, Mark G. Frattini, Christopher J. Bakkenist, Shan Zha
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07798-3
Description
Summary:ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability .
ISSN:2041-1723

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