MEDICAMENTAL IMMUNOSUPRESSION IN EARLY AGE PEDIATRIC LIVER RECIPIENTS

• Main Authors: S. V. Gautier, D. S. Mnatsakanyan
• Format: Article
• Language: Russian
• Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2012-09-01
• Series: Vestnik Transplantologii i Iskusstvennyh Organov
• Subjects: liver transplantation; immune response; calcineurin inhibitor
• Online Access: https://journal.transpl.ru/vtio/article/view/194
• ISSN: 1995-1191

The article presents analysis of scientific literature of the last 20 years about medicamental immunosupression in early age pediatric liver recipients in view of immune response characteristics and immunosuppressive drugs pharmacokinetics in such patients. The modern concept of immunosuppressive therapy protocol choice in pedia- tric liver recipients depending on complications development (nephrotoxicity, arterial hypertension and neuroto- xicity, the high risk of infectious complications, post-transplant proliferative disorders, metabolic and cosmetic side effects) is presented. Different opportunities of early steroid withdrawal, calcineurin inhibitor minimization in pediatric liver allograft recipients are covered.