The Influence of Polysaccharide Coating on the Physicochemical Parameters and Cytotoxicity of Silica Nanoparticles for Hydrophilic Biomolecules Delivery

The Influence of Polysaccharide Coating on the Physicochemical Parameters and Cytotoxicity of Silica Nanoparticles for Hydrophilic Biomolecules Delivery

The present work reports the effect of polysaccharides (chitosan and sodium alginate) on silica nanoparticles (SiNP) for hydrophilic molecules delivery taking insulin as model drug. The influence of tetraethyl orthosilicate (TEOS) and homogenization speed on SiNP properties was assessed by a 2<su...

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Bibliographic Details
Main Authors: Tatiana Andreani, Joana F. Fangueiro, Patrícia Severino, Ana Luiza R. de Souza, Carlos Martins-Gomes, Paula M. V. Fernandes, Ana C. Calpena, Maria P. Gremião, Eliana B. Souto, Amélia M. Silva
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Nanomaterials
Subjects:
silica nanoparticles
polysaccharides
insulin
hydrophilic biomolecules
factorial design
kinetic studies
cell toxicity
Online Access:https://www.mdpi.com/2079-4991/9/8/1081

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https://www.mdpi.com/2079-4991/9/8/1081

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