Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and...

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Main Authors:	Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko, Aaron J. Johnson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03037-x

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spelling	doaj-7bf1f249199b44a48e774d5c33748d092021-05-11T09:40:58ZengNature Publishing GroupNature Communications2041-17232018-02-019111310.1038/s41467-018-03037-xNon-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responsesCourtney S. Malo0Matthew A. Huggins1Emma N. Goddery2Heather M. A. Tolcher3Danielle N. Renner4Fang Jin5Michael J. Hansen6Larry R. Pease7Kevin D. Pavelko8Aaron J. Johnson9Department of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicMayo Clinic Graduate School of Biomedical Sciences, Mayo ClinicDepartment of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicDepartment of Immunology, Mayo ClinicDendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.https://doi.org/10.1038/s41467-018-03037-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Courtney S. Malo Matthew A. Huggins Emma N. Goddery Heather M. A. Tolcher Danielle N. Renner Fang Jin Michael J. Hansen Larry R. Pease Kevin D. Pavelko Aaron J. Johnson
spellingShingle	Courtney S. Malo Matthew A. Huggins Emma N. Goddery Heather M. A. Tolcher Danielle N. Renner Fang Jin Michael J. Hansen Larry R. Pease Kevin D. Pavelko Aaron J. Johnson Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses Nature Communications
author_facet	Courtney S. Malo Matthew A. Huggins Emma N. Goddery Heather M. A. Tolcher Danielle N. Renner Fang Jin Michael J. Hansen Larry R. Pease Kevin D. Pavelko Aaron J. Johnson
author_sort	Courtney S. Malo
title	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_short	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_full	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_fullStr	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_full_unstemmed	Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses
title_sort	non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating cd8 + t cell responses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.
url	https://doi.org/10.1038/s41467-018-03037-x
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Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

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