Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and...

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Bibliographic Details
Main Authors: Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko, Aaron J. Johnson
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03037-x
Description
Summary:Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.
ISSN:2041-1723

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