Correlation between steroid receptors, angiogenic factors, and classical prognostic parameters in node-negative breast cancer patients

• Main Authors: Vujasinović Tijana, Markićević M., Rabi Abu Z., Nikolić-Vukosavljević Dragica
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2009-01-01
• Series: Archives of Biological Sciences
• Subjects: breast cancer; prognosis; ER; PR; VEGF; bFGF
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640904599V.pdf

Breast cancer (BC) progression is an estrogen receptor (ER) signaling- and angiogenesis-dependent process. This study investigated relationships between classical prognostic factors and biomarkers ER, PR, VEGF, and bFGF in node-negative BC patients. Positive correlation between ER and both PR (p < 0.001) or FGF (p = 0.04) levels indicates ER-regulated expression of these factors and a potential synergistic effect of ER and bFGF in tumor progression. Aside from correlation of age with ER and bFGF levels (p = 0.003; p = 0.05; respectively), no correlation of biomarkers with classical prognostic parameters was found, indicating that those biomarkers could be independent prognostic factors.