Loss of anti-Bax function in Gerstmann-Sträussler-Scheinker syndrome-associated prion protein mutants.

Loss of anti-Bax function in Gerstmann-Sträussler-Scheinker syndrome-associated prion protein mutants.

Previously, we have shown the loss of anti-Bax function in Creutzfeldt Jakob disease (CJD)-associated prion protein (PrP) mutants that are unable to generate cytosolic PrP (CyPrP). To determine if the anti-Bax function of PrP modulates the manifestation of prion diseases, we further investigated the...

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Bibliographic Details
Main Authors: Julie Jodoin, Micheal Misiewicz, Priya Makhijani, Paresa N Giannopoulos, Jennifer Hammond, Cynthia G Goodyer, Andréa C LeBlanc
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2722024?pdf=render

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http://europepmc.org/articles/PMC2722024?pdf=render

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