Elastography for the differential diagnosis of malignant versus benign testicular lesions: a meta-analysis

• Main Authors: Ziwei Lin, Rui Lin, Huaiyu Wu, Linghu Wu, Jieying Zeng, Jinfeng Xu, Fajin Dong
• Format: Article
• Language: English
• Published: Korean Society of Ultrasound in Medicine 2021-10-01
• Series: Ultrasonography
• Subjects: testicular lesion; elastography; meta-analysis
• Online Access: http://www.e-ultrasonography.org/upload/usg-20191.pdf

Purpose The aim of this study was to evaluate the value of elastography in the differential diagnosis of benign versus malignant testicular lesions. Methods The PubMed, Cochrane Library, and Embase databases were searched for relevant studies. The diagnostic accuracy of elastography was evaluated using pooled sensitivity, specificity, likelihood ratio, post-test probability, diagnostic odds ratio, and by summarizing the area under the hierarchical summary receiver operating characteristic (HSROC) curve. Results Seven studies with 568 lesions were included. The pooled sensitivity and specificity were 87% (95% confidence interval [CI], 81% to 92%) and 81% (95% CI, 65% to 90%), respectively. The pooled estimates of the positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 4.48 (95% CI, 2.37 to 8.47), 0.16 (95% CI, 0.10 to 0.25), and 28.11 (95% CI, 11.39 to 69.36), respectively. The area under the HSROC curve was 90% (95% CI, 88% to 93%). Conclusion Elastography is useful for assessing the stiffness of testicular lesions and for differentiating benign from malignant lesions. Elastography can be an effective supplement to conventional ultrasonography.