Imunnological status in patients whis type 2 diabetes mellitus

• Main Authors: Natalya Alexandrovna Belyakova, Evgenia Vladimirovna Rudenko, Daria Gennad'evna Mikhaylova, Elena Nikolaevna Egorova, Elizaveta Georgievna Nekrasova, Elena Dmitrievna Gogina
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2011-06-01
• Series: Сахарный диабет
• Subjects: type 2 diabetes mellitus; immune status; endogenous autorosette formation
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/5627/3405
• ISSN: 2072-0351; 2072-0378

Aim. To elucidate peculiarities of autorosette formation (ARF), immunological status and associated factors in patients with type 2 diabetes mellitus. Materials and methods. The study included 148 patients with DM2 and 63 practically healthy subjects. The following parameters were measured:the number of autorosettes in peripheral blood, C-reactive protein level, and humoral immunity (from blood immunoglobulin levels); spontaneousand induced TNB tests were performed. Results. Patients with DM2 suffered disturbances of carbohydrate metabolism and had an elevated number of autorosettes in peripheral blood, dysimmunoglobulinemia,increased level of acute phase protein, impaired functional activity of neutrophils. Conclusion. Intensity of ARF increases with duration of DM2 and a rise in AP. Patients with long-standing severe DM2, AH, micro- and macroalbuminurea,hyperglycemia, and triglyceridemia experience deterioration of immunological status.