Mice with chimeric livers are an improved model for human lipoprotein metabolism.

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

OBJECTIVE:Rodents are poor model for human hyperlipidemias because total cholesterol and low density lipoprotein levels are very low on a normal diet. Lipoprotein metabolism is primarily regulated by hepatocytes and we therefore assessed whether chimeric mice extensively repopulated with human cells...

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Main Authors: Ewa C S Ellis, Willscott Edward Naugler, Paolo Parini, Lisa-Mari Mörk, Carl Jorns, Helen Zemack, Anita Lövgren Sandblom, Ingemar Björkhem, Bo-Göran Ericzon, Elizabeth M Wilson, Stephen C Strom, Markus Grompe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817217?pdf=render

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