Dendritic cell MST1 inhibits Th17 differentiation

The differentiation of Th17 cells is central to infection and autoimmunity. Here, the authors show that expression of MST1 by dendritic cells limits IL-6 production and thereby controls Th17 differentiation in immunity to fungal infection and experimental autoimmune encephalomyelitis.

Bibliographic Details
Main Authors:	Chunxiao Li, Yujing Bi, Yan Li, Hui Yang, Qing Yu, Jian Wang, Yu Wang, Huilin Su, Anna Jia, Ying Hu, Linian Han, Jiangyuan Zhang, Simin Li, Wufan Tao, Guangwei Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14275

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spelling	doaj-7bc77ada28784ea19eb14a65cc0d2d8b2021-05-11T07:18:45ZengNature Publishing GroupNature Communications2041-17232017-02-018111310.1038/ncomms14275Dendritic cell MST1 inhibits Th17 differentiationChunxiao Li0Yujing Bi1Yan Li2Hui Yang3Qing Yu4Jian Wang5Yu Wang6Huilin Su7Anna Jia8Ying Hu9Linian Han10Jiangyuan Zhang11Simin Li12Wufan Tao13Guangwei Liu14Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and EpidemiologyKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityDepartment of Immunology, School of Basic Medical Sciences, Fudan UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityState Key Laboratory of Genetic Engineering and Institute of Developmental Biology and Molecular Medicine, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan UniversityKey Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal UniversityThe differentiation of Th17 cells is central to infection and autoimmunity. Here, the authors show that expression of MST1 by dendritic cells limits IL-6 production and thereby controls Th17 differentiation in immunity to fungal infection and experimental autoimmune encephalomyelitis.https://doi.org/10.1038/ncomms14275
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chunxiao Li Yujing Bi Yan Li Hui Yang Qing Yu Jian Wang Yu Wang Huilin Su Anna Jia Ying Hu Linian Han Jiangyuan Zhang Simin Li Wufan Tao Guangwei Liu
spellingShingle	Chunxiao Li Yujing Bi Yan Li Hui Yang Qing Yu Jian Wang Yu Wang Huilin Su Anna Jia Ying Hu Linian Han Jiangyuan Zhang Simin Li Wufan Tao Guangwei Liu Dendritic cell MST1 inhibits Th17 differentiation Nature Communications
author_facet	Chunxiao Li Yujing Bi Yan Li Hui Yang Qing Yu Jian Wang Yu Wang Huilin Su Anna Jia Ying Hu Linian Han Jiangyuan Zhang Simin Li Wufan Tao Guangwei Liu
author_sort	Chunxiao Li
title	Dendritic cell MST1 inhibits Th17 differentiation
title_short	Dendritic cell MST1 inhibits Th17 differentiation
title_full	Dendritic cell MST1 inhibits Th17 differentiation
title_fullStr	Dendritic cell MST1 inhibits Th17 differentiation
title_full_unstemmed	Dendritic cell MST1 inhibits Th17 differentiation
title_sort	dendritic cell mst1 inhibits th17 differentiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-02-01
description	The differentiation of Th17 cells is central to infection and autoimmunity. Here, the authors show that expression of MST1 by dendritic cells limits IL-6 production and thereby controls Th17 differentiation in immunity to fungal infection and experimental autoimmune encephalomyelitis.
url	https://doi.org/10.1038/ncomms14275
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Dendritic cell MST1 inhibits Th17 differentiation

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