Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion

Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion

Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However, little is known about the precise mechanisms...

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Bibliographic Details
Main Authors: Mayumi Kamaguchi, Hiroaki Iwata, Yuiko Mori, Ellen Toyonaga, Hideyuki Ujiie, Yoshimasa Kitagawa, Hiroshi Shimizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
bullous pemphigoid
type XVII collagen
intravenous immunoglobulin
idiotypic antibody
depletion
autoantibody
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01669/full

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