Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients

Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients

Abstract Cystic fibrosis (CF) is a life‐limiting autosomal recessive genetic disease caused by variants in the CFTR gene, most commonly by the [F508del] variant. Although CF is a classical Mendelian disease, genetic variants in several modifier genes have been associated with variation of the clinic...

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Bibliographic Details
Main Authors: Nathan I. Walton, Xijun Zhang, Anthony R. Soltis, Joshua Starr, Clifton L. Dalgard, Matthew D. Wilkerson, Douglas Conrad, Harvey B. Pollard
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Physiological Reports
Subjects:
BMI
cystic fibrosis
TNS1
whole genome sequencing
Online Access:https://doi.org/10.14814/phy2.14886

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