Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.

Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease. Loss of function of the nuclear receptor REV-ERB is associated with reduced cognitive function in mouse models. The effect of en...

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Bibliographic Details
Main Authors: Deborah A Roby, Fernanda Ruiz, Bailey A Kermath, Jaymie R Voorhees, Michael Niehoff, Jinsong Zhang, John E Morley, Erik S Musiek, Susan A Farr, Thomas P Burris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0215004

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https://doi.org/10.1371/journal.pone.0215004

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