Circulating precursors of endothelial cells in patients with CHD and disturbed carbohydrate metabolism

• Main Authors: Maria Mikhailovna Ruda, Tatiana Igorevna Aref'eva, Angelina Valer'evna Sokolova, Marina Vladimirovna Shestakova, Yury Alexandrovich Karpov, Elena Viktorovna Parfenova
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2010-03-01
• Series: Сахарный диабет
• Subjects: circulating precursors of endothelial cells; disturbed carbohydrate metabolism; coronary heart disease
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/6011/3770
• ISSN: 2072-0351; 2072-0378

Aim. Circulating precursors of endothelial cells (PEC) play an important role in regeneration of damaged vascular endothelium and myocardium and neovascularization of ischemic tissues. The aim of this work was to study effect of disturbed carbohydrate metabolism (DCM) on the number of PEC in patients with different forms of CHD. Materials and methods. The number of PEC was determined by flow cytofluometry, insulin and C-peptide levels by IFA in 78 patients aged 40-69 (mean 55.5?0.9) years. Control groups comprised 17 subjects without CHD and DCM, 33 patients were allocated to the stable angina (SA) group (48% with DCM), 28 suffered acute coronary syndrome without segment ST elevation (ACS-ST) (39% had DCM). Results. The number of PEC was reduced in all CHD patients, by 23% in the SA group (p