The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
The sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell differentiation. When the function of SIX gene...
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2021-08-01
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doaj-7b9bb35610864c5a89dd2427e7c141722021-08-19T14:59:50ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.707854707854The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer BiologyLogan Meurer0Leonard Ferdman1Beau Belcher2Troy Camarata3Department of Basic Sciences, NYIT College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, United StatesDepartment of Basic Sciences, NYIT College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, United StatesDepartment of Biological Sciences, Arkansas State University, Jonesboro, AR, United StatesDepartment of Basic Sciences, NYIT College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, United StatesThe sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell differentiation. When the function of SIX genes becomes disrupted, distinct congenital defects develops both in animal models and humans. In addition to the embryonic setting, members of the SIX family have been found to be critical regulators of tumorigenesis, promoting cell proliferation, epithelial-to-mesenchymal transition, and metastasis. Research in both the fields of developmental biology and cancer research have provided an extensive understanding of SIX family transcription factor functions. Here we review recent progress in elucidating the role of SIX family genes in congenital disease as well as in the promotion of cancer. Common themes arise when comparing SIX transcription factor function during embryonic and cancer development. We highlight the complementary nature of these two fields and how knowledge in one area can open new aspects of experimentation in the other.https://www.frontiersin.org/articles/10.3389/fcell.2021.707854/fulltranscription factorSIX genesdevelopmental biologycancercongenital disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Logan Meurer Leonard Ferdman Beau Belcher Troy Camarata |
spellingShingle |
Logan Meurer Leonard Ferdman Beau Belcher Troy Camarata The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology Frontiers in Cell and Developmental Biology transcription factor SIX genes developmental biology cancer congenital disease |
author_facet |
Logan Meurer Leonard Ferdman Beau Belcher Troy Camarata |
author_sort |
Logan Meurer |
title |
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology |
title_short |
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology |
title_full |
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology |
title_fullStr |
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology |
title_full_unstemmed |
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology |
title_sort |
six family of transcription factors: common themes integrating developmental and cancer biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-08-01 |
description |
The sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell differentiation. When the function of SIX genes becomes disrupted, distinct congenital defects develops both in animal models and humans. In addition to the embryonic setting, members of the SIX family have been found to be critical regulators of tumorigenesis, promoting cell proliferation, epithelial-to-mesenchymal transition, and metastasis. Research in both the fields of developmental biology and cancer research have provided an extensive understanding of SIX family transcription factor functions. Here we review recent progress in elucidating the role of SIX family genes in congenital disease as well as in the promotion of cancer. Common themes arise when comparing SIX transcription factor function during embryonic and cancer development. We highlight the complementary nature of these two fields and how knowledge in one area can open new aspects of experimentation in the other. |
topic |
transcription factor SIX genes developmental biology cancer congenital disease |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.707854/full |
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