The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology

The sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell differentiation. When the function of SIX gene...

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Main Authors: Logan Meurer, Leonard Ferdman, Beau Belcher, Troy Camarata
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.707854/full
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spelling doaj-7b9bb35610864c5a89dd2427e7c141722021-08-19T14:59:50ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.707854707854The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer BiologyLogan Meurer0Leonard Ferdman1Beau Belcher2Troy Camarata3Department of Basic Sciences, NYIT College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, United StatesDepartment of Basic Sciences, NYIT College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, United StatesDepartment of Biological Sciences, Arkansas State University, Jonesboro, AR, United StatesDepartment of Basic Sciences, NYIT College of Osteopathic Medicine at Arkansas State University, Jonesboro, AR, United StatesThe sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell differentiation. When the function of SIX genes becomes disrupted, distinct congenital defects develops both in animal models and humans. In addition to the embryonic setting, members of the SIX family have been found to be critical regulators of tumorigenesis, promoting cell proliferation, epithelial-to-mesenchymal transition, and metastasis. Research in both the fields of developmental biology and cancer research have provided an extensive understanding of SIX family transcription factor functions. Here we review recent progress in elucidating the role of SIX family genes in congenital disease as well as in the promotion of cancer. Common themes arise when comparing SIX transcription factor function during embryonic and cancer development. We highlight the complementary nature of these two fields and how knowledge in one area can open new aspects of experimentation in the other.https://www.frontiersin.org/articles/10.3389/fcell.2021.707854/fulltranscription factorSIX genesdevelopmental biologycancercongenital disease
collection DOAJ
language English
format Article
sources DOAJ
author Logan Meurer
Leonard Ferdman
Beau Belcher
Troy Camarata
spellingShingle Logan Meurer
Leonard Ferdman
Beau Belcher
Troy Camarata
The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
Frontiers in Cell and Developmental Biology
transcription factor
SIX genes
developmental biology
cancer
congenital disease
author_facet Logan Meurer
Leonard Ferdman
Beau Belcher
Troy Camarata
author_sort Logan Meurer
title The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
title_short The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
title_full The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
title_fullStr The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
title_full_unstemmed The SIX Family of Transcription Factors: Common Themes Integrating Developmental and Cancer Biology
title_sort six family of transcription factors: common themes integrating developmental and cancer biology
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2021-08-01
description The sine oculis (SIX) family of transcription factors are key regulators of developmental processes during embryogenesis. Members of this family control gene expression to promote self-renewal of progenitor cell populations and govern mechanisms of cell differentiation. When the function of SIX genes becomes disrupted, distinct congenital defects develops both in animal models and humans. In addition to the embryonic setting, members of the SIX family have been found to be critical regulators of tumorigenesis, promoting cell proliferation, epithelial-to-mesenchymal transition, and metastasis. Research in both the fields of developmental biology and cancer research have provided an extensive understanding of SIX family transcription factor functions. Here we review recent progress in elucidating the role of SIX family genes in congenital disease as well as in the promotion of cancer. Common themes arise when comparing SIX transcription factor function during embryonic and cancer development. We highlight the complementary nature of these two fields and how knowledge in one area can open new aspects of experimentation in the other.
topic transcription factor
SIX genes
developmental biology
cancer
congenital disease
url https://www.frontiersin.org/articles/10.3389/fcell.2021.707854/full
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