A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity
Abstract Lung fibrosis is characterised by the accumulation of extracellular matrix within the lung and is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits gas exchange causing respiratory insufficiency. The pathogenesis of lung fibrosis is poorly understood,...
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Wiley
2019-01-01
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| Series: | Clinical & Translational Immunology |
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| Online Access: | https://doi.org/10.1002/cti2.1065 |
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doaj-7b9ad4cbde984f4b8a32d17e1bfd6a742020-11-24T22:05:01ZengWileyClinical & Translational Immunology2050-00682019-01-0186n/an/a10.1002/cti2.1065A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunityHelen I Warheit‐Niemi0Elissa M Hult1Bethany B Moore2Department of Microbiology and Immunology University of Michigan Ann Arbor MI USADepartment of Molecular and Integrative Physiology University of Michigan Ann Arbor MI USADepartment of Microbiology and Immunology University of Michigan Ann Arbor MI USAAbstract Lung fibrosis is characterised by the accumulation of extracellular matrix within the lung and is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits gas exchange causing respiratory insufficiency. The pathogenesis of lung fibrosis is poorly understood, but immunologic‐based treatments have been largely ineffective. Despite this, accumulating evidence suggests that innate immune cells and receptors play important modulatory roles in the initiation and propagation of the disease. Paradoxically, while innate immune signalling may be important for the pathogenesis of fibrosis, there is also evidence to suggest that innate immune function against pathogens may be impaired, leading to dysregulated and/or impaired host defence. This review summarises the evidence for this pathologic two‐way street, highlights new concepts of pathogenesis and recommends future directions for research emphasis.https://doi.org/10.1002/cti2.1065bacteriacollagenhost defencemacrophageneutrophilToll‐like receptors |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Helen I Warheit‐Niemi Elissa M Hult Bethany B Moore |
| spellingShingle |
Helen I Warheit‐Niemi Elissa M Hult Bethany B Moore A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity Clinical & Translational Immunology bacteria collagen host defence macrophage neutrophil Toll‐like receptors |
| author_facet |
Helen I Warheit‐Niemi Elissa M Hult Bethany B Moore |
| author_sort |
Helen I Warheit‐Niemi |
| title |
A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity |
| title_short |
A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity |
| title_full |
A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity |
| title_fullStr |
A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity |
| title_full_unstemmed |
A pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity |
| title_sort |
pathologic two‐way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity |
| publisher |
Wiley |
| series |
Clinical & Translational Immunology |
| issn |
2050-0068 |
| publishDate |
2019-01-01 |
| description |
Abstract Lung fibrosis is characterised by the accumulation of extracellular matrix within the lung and is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits gas exchange causing respiratory insufficiency. The pathogenesis of lung fibrosis is poorly understood, but immunologic‐based treatments have been largely ineffective. Despite this, accumulating evidence suggests that innate immune cells and receptors play important modulatory roles in the initiation and propagation of the disease. Paradoxically, while innate immune signalling may be important for the pathogenesis of fibrosis, there is also evidence to suggest that innate immune function against pathogens may be impaired, leading to dysregulated and/or impaired host defence. This review summarises the evidence for this pathologic two‐way street, highlights new concepts of pathogenesis and recommends future directions for research emphasis. |
| topic |
bacteria collagen host defence macrophage neutrophil Toll‐like receptors |
| url |
https://doi.org/10.1002/cti2.1065 |
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