Characterization of recombinant B. abortus strain RB51SOD towards understanding the uncorrelated innate and adaptive immune responses induced by RB51SOD compared to its parent vaccine strain RB51

Characterization of recombinant B. abortus strain RB51SOD towards understanding the uncorrelated innate and adaptive immune responses induced by RB51SOD compared to its parent vaccine strain RB51

Brucella abortus is a Gram-negative, facultative intracellular pathogen for several mammals, including humans. Live attenuated B. abortus strain RB51 is currently the official vaccine used against bovine brucellosis in the United States and several other countries. Overexpression of protective B. ab...

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Bibliographic Details
Main Authors: Jianguo eZhu, Charles Bradford Larson, Megan Ann Ramaker, Kimberly eQuandt, Jered eWendte, Kimberly eKu, Fang eChen, George eJourdian, Ramesh eVemulapalli, Gerhardt G. Schurig, Yongqun Oliver eHe
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Vaccine
innate immunity
Brucella abortus strains RB51 and RB51SOD
Cu/Zn superoxide
cytotoxic T lymphocyte (CTL)
macrophage cell death
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2011.00010/full

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