Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.

Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.

The human apolipoprotein ε4 allele (APOE4) has been implicated as one of the strongest genetic risk factors associated with Alzheimer's disease (AD) and in influencing normal cognitive functioning. Previous studies have demonstrated that mice expressing human apoE4 display deficits in behaviora...

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Bibliographic Details
Main Authors:	Rebecca C Klein, Shyla Saini, M-Louise Risher, Shawn K Acheson, Rebekah L Fleming, Hannah G Sexton, H Scott Swartzwelder, Scott D Moore
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3986067?pdf=render

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