B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells

Summary: Type 1 interferon (T1IFN) signaling promotes inflammation and lupus pathology, but its role in autoreactive B cell development in the antibody-forming cell (AFC) and germinal center (GC) pathways is unclear. Using a lupus model that allows for focused study of the AFC and GC responses, we s...

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Bibliographic Details
Main Authors: Phillip P. Domeier, Sathi Babu Chodisetti, Stephanie L. Schell, Yuka Imamura Kawasawa, Melinda J. Fasnacht, Chetna Soni, Ziaur S.M. Rahman
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718309562

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http://www.sciencedirect.com/science/article/pii/S2211124718309562

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