Phagocytosis Effectivity Test of Phenylbutenoid Compounds Isolated from Bangle (Zingiber cassumunar Roxb.) Rhizome

• Main Authors: CHAIRUL, PRAPTIWI, SOFNIE MARUSIN CHAIRUL
• Format: Article
• Language: English
• Published: MBI & UNS Solo 2009-01-01
• Series: Biodiversitas
• Subjects: Zingiber cassumunar Roxb; immunostimulant; phenylbutenoid derivative; [(E)-4-(3’; 4’-dimethoxyphenyl)but-3-en-1-ol]; [(E)-4-(2’; 4’; 5’-trimethoxyphenyl)but-3-en-1-ol]and [(E)-4-(3’; 1-trimethoxy phenyl)but-3-en-1-ol]
• Online Access: http://biodiversitas.mipa.uns.ac.id/D/D1001/D100108.pdf

This study was conducted to determine the immunostimulant activity of several phenylbutenoid derivatives isolated from bangle (Zingiber cassumunar Roxb) rhizome: [1] [(E)-4-(3’,4’-dimethoxyphenyl)but-3-en-1-ol], [2] [(E)-4-(2’,4’,5’-tri-methoxyphenyl)but-3-en-1-ol] and [3] [(E)-4-(3’,4’,1-trimethoxyphenyl)but-3-en-1-ol]. Immunostimulant activity was done by stimulating macrophage cells of mouse peritoneum. The result showed that [(E)-4-(3’,4’-dimethoxyphenyl)but-3-en-1-ol] compound had highest immunostimulant activity (99.0%) compared to compound 2 (93.7%) and 3 (80.0%).