Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide.

Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide.

Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced...

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Bibliographic Details
Main Authors: Manoj Paul, Mahadevappa Hemshekhar, Ram M Thushara, Mahalingam S Sundaram, Somanathapura K NaveenKumar, Shivanna Naveen, Sannaningaiah Devaraja, Kumar Somyajit, Robert West, Basappa, Siddaiah C Nayaka, Uzma I Zakai, Ganesh Nagaraju, Kanchugarakoppal S Rangappa, Kempaiah Kemparaju, Kesturu S Girish
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0127558

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