Insulin-like growth factor-1 and myocardial remodeling in female patients with arterial hypertension and metabolic syndrome

• Main Authors: A. N. Zakirova, E. R. Fatkullina, N. E. Zakirova, L. M. Zhamalov
• Format: Article
• Language: English
• Published: Stolichnaya Izdatelskaya Kompaniya 2015-11-01
• Series: Racionalʹnaâ Farmakoterapiâ v Kardiologii
• Subjects: инсулиноподобный фактор роста-1; ремоделирование миокарда; артериальная гипертония; ожирение
• Online Access: http://www.rpcardio.ru/jour/article/view/322
• ISSN: 1819-6446; 2225-3653

<p class="p1"><span class="s1">Aim. To establish the role of insulin-like growth factor-1 (IGF-1) in left ventricular remodeling in female patients with arterial hypertension (HT) and metabolic syndrome (MS) with different stages of obesity.<br /> Material and methods. The study included 108 women with HT and MS, who were divided into 3 groups according to the stage of obesity, and 28 healthy women. The level of IGF-1, hemodynamic status and types of left ventricular remodeling were assessed. </span></p><p class="p1"><span class="s1">Results. Concentric remodeling and IGF-1 elevation (165.3±12.03 ng/ml) prevailed in patients with HT and first stage of obesity. Concentric hypertrophy of left ventricle and normal level of IGF-1 (118.5±10.05 ng/ml) were established in patients with second stage of obesity. Lack of IGF-1 (96.4±8.11 ng / ml) was determined in women with third stage of obesity and eccentric hypertrophy. Correlation analysis in patients with 2-3 stages of obesity showed significant associations between the level of IGF-1 and hemodynamic parameters. </span></p><p class="p1"><span class="s1">Conclusion. Changes in the level of IGF-1 in patients with AH and MS correlate with types of remodeling and stage of obesity. </span></p>